Researchers have developed a new cost-effective microscopy method to accurately identify people with a rare bleeding disorder.
Using the super-resolution microscopy method called Structured Illumination Microscopy (SIM), the researchers were able to differentiate between patients with a rare bleeding disorder and healthy volunteers, according to the study.
"We have found that SIM has a lot of advantages over whole mount electron microscopy as a diagnosis method," said study first author David Westmoreland from the University College London.
"Samples do not need to be analysed live and can be reanalysed, and automation means analysis is unbiased and less time-consuming," Westmoreland noted.
"Given about 75 percent of patients with a bleeding disorder such as Hermansky-Pudlak Syndrome are initially misdiagnosed and 28 percent need to see between four to six specialists before receiving the correct diagnosis, there is a demand for a new method of analysis," Westmorel explained.
For the study, the team used Structured Illumination Microscopy to specifically image platelet granules in blood samples using a marker protein, CD63.
Platelets form part of the blood and they help heal wounds and prevent bleeding by forming blood clots.
Results of the study will be published in the Journal of Thrombosis and Haemostasis.